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Callum Hudson-Odoi has suffered a recurrence of a hamstring injury, with Mateo Kovacic sidelined due to an Achilles problem and Willian a doubt for a similar issue.
Jorginho starts a two-match league suspension, with N’Golo Kante (adductor) and Tammy Abraham (ankle) out, and Andreas Christensen (knock), Christian Pulisic (adductor) and Ruben Loftus-Cheek (Achilles) all doubts.
least the next two matches with the thigh problem that forced him off against Manchester United last weekend.
Lucas Digne has recovered from a calf problem but Cenk Tosun – who suffered an ACL injury on loan at Crystal Palace – has joined Morgan Schneiderlin (also knee) and Jean-Philippe Gbamin (thigh) as a long-term absentee.